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Updated: Dec 24, 2025

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
Published on: June 9, 2023
Controlling carbon encapsulation of gold nano-aggregates as highly sensitive and spectrally stable SERS tags for live
Guannan Zhang1, Gan Qu, Yong Chen
1Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry & Molecular Sciences, Wuhan University, Wuhan, 430072, China. agshen@whu.edu.cn jmhu@whu.edu.cn.
Abstract:
We describe a highly sensitive and spectrally stable surface-enhanced Raman scattering (SERS) tag for live cell imaging based on carbon-encapsulated gold nano-aggregates (CEGNAs). Our findings reveal that controlling the synthesis of the gold nano-aggregate core can be achieved under the mediation of cetyltrimethylammonium bromide (CTAB) through electrostatic forces and hydrophobic interactions, and as the number of particles in the aggregates increase, the relative SERS activity also increases hugely.
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