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Tissue distribution of ketamine: two case reports.
S H Peyton1, A T Couch, R O Bost
1Southwestern Institute of Forensic Sciences, Dallas, Texas 75235.
Journal of Analytical Toxicology
|September 1, 1988
Summary
Ketamine overdose caused one death, while another involved a gunshot victim who received ketamine during surgery. Both cases detail ketamine distribution within the body, offering crucial forensic insights.
Area of Science:
- Forensic Toxicology
- Pharmacology
- Medical Case Reports
Background:
- Ketamine is an anesthetic with known psychoactive and dissociative effects.
- Understanding ketamine's distribution and metabolism is critical for forensic investigations and clinical safety.
Observation:
- Two distinct cases of mortality involving ketamine administration are presented.
- Case 1: Death attributed to ketamine overdose.
- Case 2: Death in a gunshot victim following ketamine administration during surgical intervention.
Findings:
- Detailed analysis of ketamine distribution in bodily tissues and fluids for both deceased individuals.
- Pharmacokinetic data derived from post-mortem examinations.
Implications:
- Highlights the importance of careful ketamine dosage and administration, even in emergency surgical settings.
- Provides valuable data for forensic toxicologists investigating ketamine-related deaths.
- Contributes to the understanding of ketamine's systemic effects and distribution patterns in critical scenarios.