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Updated: Dec 24, 2025

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
Published on: May 26, 2016
Hybrid polymersomes: facile manipulation of vesicular surfaces for enhancing cellular interaction
Xingfang Su1, Shaqireen Kwajah Mohamed Moinuddeen, Lucia Mori
1Institute of Materials Research and Engineering (A*STAR), 3 Research Link, Singapore 117602. nallanim@imre.a-star.edu.sg.
Abstract:
Facile surface modification via the blending of lipids and block-co-polymers to assemble hybrid vesicles was investigated for improving cellular interaction and antigen delivery of poly(ethylene glycol) (PEG)-based polymersomes. Cationic lipids (DOTAP) incorporated into PEG-b-PBD polymersomes increased the binding and uptake of vesicles by antigen-presenting cells, while preserving the stability and biocompatibility of PEG-based polymersomes, resulting in the enhanced cellular delivery of a loaded lipid antigen sulfatide.
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