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Updated: Dec 24, 2025
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
A versatile method for the preparation of poly-acrylamide derivative functionalized thermo-responsive gold
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun No. 2 Beiyijie, 100190, P.R. China. qili@iccas.ac.cn.
Abstract:
In this work, we present a facile in situ strategy for synthesis of thermo-responsive gold nanoparticles (GNPs) at room temperature. By using the RAFT polymerization methods, thermo-responsive polymer chains possessing trithiocarbonate groups have been synthesized which can be split into two chains and can produce a thiol end-group by NaOH. Then the thiol end-group polymer chains can act as anchors to capture the Au(iii) ions in aqueous solution to form thermo-responsive GNPs. The thermo-responsive GNPs synthesized by the proposed method exhibited a reversible, clear-opaque transition in solution between 35 °C and 60 °C. It is conjectured that this strategy possesses the virtues including in situ, "green", universal and tailored without a tedious reducing procedure using any toxic reducing agents. Further, the thermo-responsive GNPs have been applied for the effective analysis of cysteine in urine samples.
