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Updated: Dec 24, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Injectable biodegradable hydrogels: progress and challenges.

Ki Hyun Bae¹, Li-Shan Wang, Motoichi Kurisawa

¹Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos #04-01, Singapore 138669. mkurisawa@ibn.a-star.edu.sg.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

This summary is machine-generated.

Injectable biodegradable hydrogels offer biocompatible, minimally invasive solutions for delivering proteins, genes, and cells. These versatile biomaterials also function as temporary extracellular matrices for tissue engineering and biomedical adhesives.

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Area of Science:

Biomaterials Science
Drug Delivery
Tissue Engineering

Background:

Injectable hydrogels are advanced biomaterials known for biocompatibility, permeability, and minimal invasiveness.
They serve as effective systems for administering bioactive agents like proteins, genes, and cells.
These hydrogels can be designed for degradation and clearance post-administration.

Purpose of the Study:

To review state-of-the-art strategies for designing injectable biodegradable hydrogels.
To explore their applications in protein drug delivery and tissue engineering.
To discuss their use in gene delivery and as biomedical adhesives.

Main Methods:

Review of current research and strategies in injectable hydrogel design.
Analysis of hydrogel properties for drug delivery and tissue regeneration.
Exploration of applications in gene therapy and wound closure.

Main Results:

Injectable hydrogels provide a versatile platform for controlled release of therapeutics.
They act as effective temporary scaffolds for tissue engineering applications.
Hydrogels show promise in gene delivery and as advanced biomedical adhesives.

Conclusions:

Rational design of injectable biodegradable hydrogels is crucial for optimizing therapeutic delivery and tissue regeneration.
These hydrogels represent a significant advancement in biomaterials for diverse biomedical applications.
Further research will continue to expand their utility in medicine.