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Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Sae Rom Choi1, Dong-Jin Jang, Sanghyun Kim

  • 1Department of Chemical and Biological Engineering, Korea University, Seoul 136-701, Republic of Korea. jbkim3@korea.ac.kr.

Journal of Materials Chemistry. B
|April 9, 2020
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Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
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