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Updated: Dec 24, 2025

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Fast preparation of free-standing nanohydroxyapatite-vertically aligned carbon nanotube scaffolds
Marco A V M Grinet1, Hudson Zanin, Alessandro Eustaquio Campos Granato
1Laboratory of Biomedical Nanotechnology, Institute of Research and Development, Universidade do Vale do Paraiba, Av. Shishima Hifumi 2911, Sao Jose dos Campos, São Paulo, BrazilCEP: 12224-000. fermarciano@uol.com.br loboao@yahoo.com aolobo@univap.br.
Abstract:
We present a simple, low cost, and fast method to produce free-standing nanohydroxyapatite/carbon-based scaffolds. We electrodeposited nanohydroxyapatite onto vertically aligned carbon nanotube flakes and reticulated vitreous carbon bars. We prepared a highly crystalline and homogeneous thin film without any post-thermal treatment, and our results evidence that we can control the nanohydroxyapatite crystal formation according to the substrate employed. Immersion tests using simulated body fluid showed that these new nanobiomaterials had in vitro bioactivity. The free-standing nanohydroxyapatite/carbon-based scaffolds have been shown to be a suitable surface for mesenchymal stem cell adhesion with active formation of membrane projections and cell monolayer formation.

