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Light-triggered CO release from nanoporous non-wovens.

Carmen Bohlender¹, Steve Gläser, Moritz Klein

¹Friedrich Schiller University Jena, Institute for Inorganic and Analytical Chemistry (IAAC), Humboldtstr. 8, 07743 Jena, Germany. alexander.schiller@uni-jena.de.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

This study embeds photoactive carbon monoxide-releasing molecule-1 (CORM-1) into polymer fibers, creating a material that releases CO upon light exposure. This light-activated material is non-toxic in the dark but photocytotoxic, offering potential therapeutic applications.

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Area of Science:

Biomaterials Engineering
Materials Science
Photochemistry

Background:

Carbon monoxide-releasing molecules (CORMs) offer therapeutic potential but often suffer from poor bioavailability.
Developing methods to control CO release and enhance CORM delivery is crucial for biomedical applications.

Purpose of the Study:

To embed the photoactive CORM-1 into poly(l-lactide-co-d/l-lactide) fibers using electrospinning.
To characterize the resulting hybrid material and assess its CO release properties and biological effects.

Main Methods:

Non-covalent embedding of CORM-1 into polymer fibers via electrospinning.
Scanning Electron Microscopy (SEM) for morphology analysis.
Infrared (IR) spectroscopy for chemical characterization.
Quantification of CO release using myoglobin assay, CO electrode, and IR gas cuvette.
In vitro cytotoxicity assays using mouse fibroblast 3T3 cells.

Main Results:

Electrospinning successfully produced hybrid non-woven fibers with a nanoporous morphology, partly due to CO release during processing.
Incorporated CORM-1 retained its carbonyl band signature, confirmed by IR spectroscopy.
Light-triggered CO release was confirmed, with release rates dependent on wavelength (365 nm faster than 480 nm).
The material generated up to 3.4 μmol of CO per mg of non-woven.
The hybrid material exhibited no dark toxicity but demonstrated significant photocytotoxicity against 3T3 cells upon light irradiation.

Conclusions:

Electrospun poly(lactide) fibers effectively encapsulate CORM-1, enhancing its bioavailability and enabling controlled, light-triggered CO release.
The developed material is biocompatible in the absence of light and exhibits potent photocytotoxicity, indicating its potential for light-activated therapies.