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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

NIR luminescent nanomaterials for biomedical imaging.

Rui Wang¹, Fan Zhang

¹Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China. zhang_fan@fudan.edu.cn.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

This review highlights near-infrared (NIR) imaging nanomaterials for deep tissue bioimaging. These NIR nanoprobes enable sensitive, real-time whole-animal imaging without dissection, overcoming limitations of visible light imaging.

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Published on: March 9, 2017

Area of Science:

Materials Science
Biomedical Engineering
Nanotechnology

Background:

Luminescent labels are crucial for bioimaging and assays.
Near-infrared (NIR) light (650-1450 nm) offers minimal tissue absorbance and autofluorescence, enabling deep tissue penetration.
Existing reviews inadequately cover NIR imaging nanomaterials.

Purpose of the Study:

To provide a comprehensive review of NIR imaging nanomaterials.
To focus on nanomaterials emitting or being excited in the NIR I (650-900 nm) and NIR II (1000-1450 nm) regions.
To summarize recent advances in fabrication and biomedical imaging applications.

Main Methods:

Systematic review of scientific literature on NIR imaging nanomaterials.
Focus on lanthanide-based nanoparticles, carbon-based nanoparticles, quantum dots, and noble metal nanomaterials.
Analysis of fabrication methods and applications in biomedical imaging.

Main Results:

NIR nanoprobes facilitate deep penetration of light into tissues.
Enables high-sensitivity, real-time whole-animal imaging in core organs without dissection.
Covers various NIR nanomaterial types including lanthanide, carbon, quantum dots, and noble metals.

Conclusions:

NIR imaging nanomaterials are critical for advanced biomedical imaging.
Significant progress has been made in their fabrication and application.
Further research is needed to address challenges and explore new opportunities in the field.