Biophysical characterisation, antitumor activity and MOF encapsulation of a half-sandwich ruthenium(ii)
S Rojas1, E Quartapelle-Procopio, F J Carmona
1Departamento de Química Inorgánica, Universidad de Granada, Av. Fuentenueva, S/N, 18071, Granada, Spain. jarn@ugr.es ebaream@ugr.es.
Abstract:
The novel non-conventional metallodrug [(η6-p-cymene)2Ru2mitoxantronato]Cl2 (1) exhibits redox activity, DNA intercalation ability, cathepsin B and D inhibition and in vitro antitumor activity able to circumvent cisplatin resistance. Moreover, 1 can be successfully incorporated into MIL100(Fe) as a proof of concept of the feasibility of metal-organic frameworks as carriers of non-conventional drugs.
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