Dopamine amperometric detection at a ferrocene clicked PEDOT:PSS coated electrode

Area of Science:

• Electroanalytical Chemistry
• Materials Science
• Nanotechnology

Background:

• Chemically modified electrodes are crucial for anchoring redox mediators.
• Strong immobilization of redox mediators on electrode surfaces is a key challenge.

Purpose of the Study:

• To develop ferrocene-functionalized PEDOT:PSS coated indium tin oxide (ITO) electrodes.
• To assess the electroanalytical performance of the modified electrodes for dopamine detection.

Main Methods:

• Two-step electrode modification: electrodeposition of PEDOT:N3 followed by copper-catalyzed azide-alkyne cycloaddition with ethynylferrocene.
• Characterization using X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and cyclic voltammetry (CV).
• Electrochemical analysis of dopamine (DA).

Main Results:

• Successful ferrocene immobilization confirmed by XPS.
• Stable and reversible ferrocene redox response observed via CV.
• The sensor exhibited a linear range of 0.01–0.9 mM for dopamine, with a mean sensitivity of 196 mA M⁻¹ cm⁻² and a limit of detection (LoD) of 1 µM.

Conclusions:

• The developed ferrocene-functionalized PEDOT:PSS/ITO electrode offers a robust platform for electroanalytical applications.
• The sensor shows excellent performance for sensitive and selective dopamine detection.
• This approach provides a reliable method for immobilizing redox mediators on electrode surfaces.