Exit-strategies - smart ways to release phospholipid vesicle cargo
Denia Mellal1, Andreas Zumbuehl
1Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland. andreas.zumbuehl@unifr.ch.
Abstract:
This highlight describes recent trends in fundamental phospholipid research towards possible future drug delivery technology. In particular it focuses on synthetic phospholipids and their vesicular constructs and describes selected "smart" ways to release cargo from liposomes. Various chemical and physical release triggers are discussed such as temperature changes, application of ultrasound, enzyme degradation, changes in pH, redox reactions, photochemical reactions, as well as the effects of shear stress on vesicles.
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