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Chitosan scaffolds with a shape memory effect induced by hydration.

Cristina O Correia1, João F Mano

  • 13B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; AvePark, Zona Industrial da Gandra S. Cláudio do Barco, 4806-909 Caldas das Taipas, Guimarães, Portugal.

Journal of Materials Chemistry. B
|April 9, 2020
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Summary
This summary is machine-generated.

Chitosan scaffolds exhibit shape memory effects triggered by hydration, enabling temporary shape fixation and recovery. These biomaterials show potential for minimally invasive surgery applications like tissue regeneration and drug delivery.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Chitosan is a versatile biopolymer with potential applications in biomedical fields.
  • Shape memory polymers offer unique possibilities for advanced material design.
  • Developing functional scaffolds is crucial for tissue engineering and drug delivery systems.

Purpose of the Study:

  • To investigate the shape memory effect of chitosan-based porous scaffolds.
  • To evaluate the influence of hydration and crosslinking on scaffold properties.
  • To assess the suitability of these scaffolds for drug delivery and minimally invasive surgery.

Main Methods:

  • Hydromechanical compressive tests and dynamic mechanical analysis (DMA) were employed.
  • Scaffolds were tested in varying water-ethanol mixtures to induce dehydration and hydration.
  • In vitro drug delivery studies were conducted.

Main Results:

  • Chitosan scaffolds demonstrated significant shape memory properties.
  • High shape fixity ratios (>97.2% for CHT0, >99.2% for CHT1) and recovery ratios (>70.5% for CHT0, >98.5% for CHT1) were achieved.
  • Scaffolds successfully delivered loaded molecules in vitro.

Conclusions:

  • Chitosan-based porous scaffolds possess tunable shape memory effects driven by hydration.
  • These scaffolds are promising candidates for advanced biomaterials in minimally invasive surgery, tissue regeneration, and controlled drug delivery.