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A photonic glucose biosensor for chronic wound prognostics.

Fransiska S H Krismastuti1, William L A Brooks, Martin J Sweetman

  • 1Mawson Institute, University of South Australia, Adelaide, South Australia 5095, Australia. nico.voelcker@unisa.edu.au.

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Monitoring glucose in diabetic wound fluid shows promise for healing. Phenylboronic acid polymers on porous silicon detect glucose using optical changes, enabling early intervention.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Medical Diagnostics

Background:

  • Monitoring glucose in chronic wound fluid is crucial for diabetic wound healing.
  • Phenylboronic acid polymers offer glucose- and pH-responsive properties for sensing applications.
  • Existing methods for wound fluid glucose monitoring present challenges in accuracy and interference.

Purpose of the Study:

  • To develop a novel theranostic approach for monitoring glucose levels in diabetic chronic wound fluid.
  • To functionalize porous silicon (pSi) films with poly(4-vinylphenylboronic acid) (PVPBA) for glucose sensing.
  • To evaluate the performance of the pSi-PVPBA composite in detecting glucose in buffer solutions and wound fluid.

Main Methods:

  • Covalent grafting of poly(4-vinylphenylboronic acid) (PVPBA) onto porous silicon (pSi) films.
  • Utilizing interferometric reflectance spectroscopy (IRS) to monitor polymer response to pH and glucose.
  • Investigating refractive index changes and effective optical thickness (EOT) variations in the pSi-PVPBA composite.

Main Results:

  • The pSi-PVPBA composite demonstrated measurable changes in effective optical thickness (EOT) due to polymer switching.
  • Successful detection of glucose in buffer solutions down to 0.15 mM was achieved.
  • The sensing platform showed no interference when analyzing glucose in actual wound fluid samples.

Conclusions:

  • The developed pSi-PVPBA composite serves as a viable platform for glucose detection in chronic wound fluid.
  • This theranostic approach holds potential for improved management and healing of diabetic wounds.
  • The sensitivity and specificity of the sensor pave the way for real-time glucose monitoring in complex biological samples.