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Ultrabright NIR fluorescent mesoporous silica nanoparticles.

S Palantavida1, R Tang, G P Sudlow

  • 1Departments of Mechanical Engineering, Tufts University, Medford, MA 02155, USA. igor.sokolov@tufts.edu achilefus@mir.wustl.edu.

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|April 9, 2020
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Summary

Researchers developed ultrabright, near-infrared fluorescent silica nanoparticles for biomedical imaging. These stable, biocompatible nanoparticles show enhanced brightness and cellular uptake, aiding early disease diagnosis.

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Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Materials Science

Background:

  • Near-infrared (NIR) fluorescent tags are crucial for biomedical imaging.
  • Developing bright, stable, and biocompatible NIR nanoparticles can improve early disease diagnosis.

Purpose of the Study:

  • To synthesize and characterize ultrabright, water-dispersible, NIR fluorescent mesoporous silica nanoparticles.
  • To evaluate their properties for potential biomedical imaging applications.

Main Methods:

  • Synthesis of mesoporous silica nanoparticles encapsulating the NIR dye LS277.
  • Characterization of particle size, fluorescence properties (excitation/emission wavelengths, quantum yield, absorptivity), and brightness.
  • Assessment of cellular internalization in 4T1luc breast tumor cells and photostability.

Main Results:

  • Synthesized nanoparticles (28 ± 3 nm) exhibit ultrabright fluorescence with peak excitation/emission at 804/815 nm.
  • Encapsulation increased the dye's quantum yield to 1.5% and absorptivity to 2.1 × 10^8 M^-1 cm^-1.
  • Particles are over 2000x brighter than individual dye molecules and 4x brighter than commercial quantum dots (QD800).
  • Nanoparticles were readily internalized by 4T1luc cells and maintained brightness for over 9 weeks.

Conclusions:

  • The synthesized NIR mesoporous silica nanoparticles offer superior brightness, stability, and biocompatibility for biomedical imaging.
  • Their enhanced properties and cellular uptake demonstrate significant potential for early disease diagnosis and tracking.