Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhancing Conductivity in 3D Organic Electrochemical Transistors with PEDOT-Tetramethacrylate Integration.

ACS materials letters·2026

Same author

Protocol for Post-Mortem Micro-CT Imaging of Coronary Arteries in Low-Mass Neonatal Puppy Hearts Using Barium-Based Contrast.

Animals : an open access journal from MDPI·2026

Same author

A preclinical large-animal evaluation of a 3D bioprinted bionic pancreatic tissue model built on simplified vascular architecture.

Biofabrication·2026

Same author

AI for bioactive materials: From material design to biological applications.

Bioactive materials·2026

Same author

Decoupling shape retention from polymerization kinetics enables ambient-temperature 3D printing of polystyrene.

Materials horizons·2026

Same author

Targeted delivery of a plant-derived monoclonal antibody using pulsed electric fields in a 3D glioblastoma model.

Bioelectrochemistry (Amsterdam, Netherlands)·2026

Same journal

Melanocortin 1 receptor-targeted peptide-functionalized liposomes for enhanced melanocyte-preferential drug delivery and anti-melanogenic efficacy.

Journal of materials chemistry. B·2026

Same journal

Recent progress in side-chain amino acid-based polymers: synthesis, self-assembly, and emerging biomedical applications.

Journal of materials chemistry. B·2026

Same journal

Bioinspired electrospun nanofibrous dressings loaded with Mentha-derived exosome-like vesicles for antibacterial and immunomodulatory burn healing.

Journal of materials chemistry. B·2026

Same journal

On demand functionality of an NIR-enhanced nanozyme catalyst for infected wound healing.

Journal of materials chemistry. B·2026

Same journal

Positively charged, phenolic hydroxyl and anthraquinone structured polystyrene microspheres targeting dual elimination of bacterial pathogens and pathogen-associated molecular patterns for sepsis therapy.

Journal of materials chemistry. B·2026

Same journal

Carbon dot-decorated Ni-MOF heterojunction sonozymes for enhanced sonodynamic-chemodynamic cancer therapy.

Journal of materials chemistry. B·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 24, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Highly ordered and tunable polyHIPEs by using microfluidics.

Marco Costantini¹, Cristina Colosi, Jan Guzowski

¹Department of Chemistry, Sapienza University of Rome, 00185 Rome, Italy. andrea.barbetta@uniroma1.it.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

This summary is machine-generated.

Researchers created ordered porous materials from dextran-methacrylate (DEX-MA) using microfluidics. This technique precisely controls pore size and interconnects for advanced tissue engineering scaffolds.

More Related Videos

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Related Experiment Videos

Last Updated: Dec 24, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Area of Science:

Materials Science
Biomaterials Engineering
Microfluidics

Background:

Developing ordered porous materials is crucial for advanced applications like tissue engineering.
Existing methods often lack precise control over structural parameters.
Dextran-methacrylate (DEX-MA) offers potential as a biocompatible scaffold material.

Purpose of the Study:

To demonstrate a microfluidic method for fabricating highly ordered porous matrices from DEX-MA.
To achieve precise control over the structural properties of the porous materials.
To explore the potential of these materials as scaffolds for tissue engineering.

Main Methods:

Utilizing a microfluidic flow focusing device to create monodisperse droplets of DEX-MA in an organic solvent.
Forming an ordered high internal phase emulsion (HIPE) at high volume fractions (>74% v/v).
Stabilizing the HIPE structure through gelling to create polyHIPEs.

Main Results:

Successfully generated highly ordered porous matrices with interconnected morphologies.
Achieved precise control over porosity, pore size (hundreds of micrometers), and interconnect lumen (tens of micrometers).
Demonstrated the ability to tune all structural parameters of the resulting polyHIPEs.

Conclusions:

The microfluidic technique enables the production of precisely tailored, ordered porous DEX-MA polyHIPEs.
These materials represent a novel class of scaffolds with tunable properties.
The developed scaffolds hold significant promise for applications in tissue engineering.