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Hydrogels for tissue engineering and regenerative medicine.

John A Hunt1, Rui Chen, Theun van Veen

  • 1Clinical Engineering, Institute of Ageing and Chronic Disease, University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, UK. huntja@liv.ac.uk.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary

Injectable hydrogels are key in tissue engineering and regenerative medicine due to their tissue-like properties and ease of use. This review covers natural and synthetic hydrogel fabrication and applications in tissue repair.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Injectable hydrogels are widely researched for tissue engineering and regenerative medicine.
  • Their high water content, mechanical properties, and ease of implantation make them ideal for biomedical scaffolds and drug delivery.
  • Hydrogels are at the forefront of designing advanced materials for therapeutic applications.

Purpose of the Study:

  • To review the current state-of-the-art in natural and synthetic injectable hydrogels.
  • To compare and contrast various chemistries for hydrogel synthesis and fabrication.
  • To discuss hydrogel applications in specific areas of tissue engineering and regenerative medicine (TERM).

Main Methods:

  • Literature review of natural and synthetic hydrogel synthesis and fabrication.
  • Comparison of different chemical approaches for creating biomedical hydrogels.
  • Analysis of hydrogel modifications for enhancing tissue repair in various adult tissues.

Main Results:

  • Hydrogels offer versatile platforms for tissue engineering due to tunable properties.
  • Both natural and synthetic materials provide distinct advantages for hydrogel development.
  • Specific modifications enable hydrogels to address diverse tissue damage and disease.

Conclusions:

  • Injectable hydrogels represent a versatile class of materials with significant potential in regenerative medicine.
  • Understanding hydrogel synthesis and chemistry is crucial for optimizing their performance.
  • Tailored hydrogel designs can effectively augment repair across a wide range of adult tissues.