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Updated: Dec 24, 2025
IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
Published on: November 13, 2023
Anionic fibroin-derived polypeptides accelerate MSC osteoblastic differentiation in a three-dimensional osteoid-like
B Marelli1, C E Ghezzi, A Alessandrino
1Department of Mining and Materials Engineering, McGill University, Montréal, QC, H3A 0C5, Canada. showan.nazhat@mcgill.ca benedetto.marelli@mail.mcgill.ca.
Abstract:
Incorporation of anionic fibroin derived polypeptides into dense collagen gels provided a dynamic, three-dimensional, tissue-equivalent matrix together with biochemical cues that resembled the role of the bone morphogenic growth factors commonly used to promote osteogenic differentiation of mesenchymal stem cells.
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