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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
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Biodegradable electroactive polymers for electrochemically-triggered drug delivery.

John G Hardy1, David J Mouser, Netzahualcóyotl Arroyo-Currás

  • 1Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA. johnhardyuk@gmail.com.

Journal of Materials Chemistry. B
|April 9, 2020
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Summary

Researchers developed new biodegradable electroactive polymer (EAP) materials for drug delivery. These EAP-based devices can release drugs like dexamethasone phosphate upon electrical stimulation and are suitable for implantable applications.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Electroactive polymers (EAPs) offer potential for advanced drug delivery systems.
  • Biodegradable materials are crucial for minimizing long-term medical device complications.
  • Controlled drug release is essential for effective therapeutic outcomes.

Purpose of the Study:

  • To synthesize and characterize novel biodegradable electroactive polymers (EAPs).
  • To evaluate the potential of these EAP-based materials as stimuli-responsive drug delivery devices.
  • To assess the in vitro degradability and cell compatibility of the synthesized polymers.

Main Methods:

  • Synthesis of copolymers linking oligoaniline-based electroactive blocks with polyethylene glycol or polycaprolactone via ester bonds.
  • Characterization of physicochemical and electrochemical properties using various techniques.
  • Spectroscopic analysis of drug (dexamethasone phosphate) release upon electrochemical stimulation.

Main Results:

  • Successfully synthesized biodegradable EAP copolymers from readily available materials.
  • Demonstrated tunable physicochemical and electrochemical properties.
  • Confirmed electrochemically triggered drug delivery of dexamethasone phosphate.
  • Showcased in vitro film degradability and cell adhesion.

Conclusions:

  • Developed promising biodegradable EAP materials for drug delivery applications.
  • These materials are suitable for implantable, fully biodegradable devices.
  • Potential for precise chronopharmacology control in future clinical applications.