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Bioactivated protein-based porous microcarriers for tissue engineering applications.

Baiwen Luo1, Qiu Li Loh, Marcus Thien Chong Wong

  • 1School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. cleochoong@ntu.edu.sg.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed novel porous microcarriers from ovalbumin (OVA) and enhanced them with human lipoaspirate-derived extracellular matrix (LpECM). These bioactivated OVA-LpECM microcarriers show improved mechanical strength and promote cell growth for tissue engineering applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Microcarriers are crucial for cell attachment in tissue engineering.
  • Ovalbumin (OVA), an inexpensive avian protein, has potential but limited research for microcarrier applications.
  • Extracellular matrix (ECM) enhances cell-material interactions but requires efficient sourcing.

Purpose of the Study:

  • To fabricate porous ovalbumin (OVA) microcarriers and investigate the impact of OVA-alginate ratios.
  • To conjugate human lipoaspirate-derived extracellular matrix (LpECM) onto OVA microcarriers to improve bioactivity.
  • To explore a waste-to-resource strategy for obtaining ECM material for biomaterial functionalization.

Main Methods:

  • Fabrication of porous OVA microcarriers with varying OVA-to-alginate ratios.
  • Isolation of ECM from human lipoaspirate via physical decellularization.
  • Conjugation of LpECM to OVA microcarriers using carbodiimide chemistry.

Main Results:

  • Optimized OVA-alginate ratios yielded porous microcarriers with specific properties.
  • Lipoaspirate-derived ECM (LpECM) was successfully obtained and conjugated.
  • The resulting OVA-LpECM hybrid microcarriers exhibited enhanced mechanical strength and promoted cellular growth.

Conclusions:

  • Porous OVA microcarriers can be successfully fabricated and functionalized with LpECM.
  • LpECM coating confers bioactivity, improving mechanical properties and cell proliferation.
  • These bioactivated OVA-LpECM microcarriers offer a promising platform for tissue engineering.