Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence-based models for colorectal cancer diagnosis using laboratory tests: an exploratory retrospective case-control study.

Translational cancer research·2026
Same author

A Covalent Targeted Platform for Protein Dynamic Tracking.

Analytical chemistry·2026
Same author

Caged Ligand-Decorated Near-Infrared Photosensitizer with In Vivo Albumin-Hijacking Capacity for Tumor-Targeted Hypoxia-Tolerant Photoimmunotherapy of Cancer.

Journal of the American Chemical Society·2026
Same author

Functionalized two-dimensional nanochannel membranes to distinguish methylated/unmethylated peptides for sensing cellular G9a protein.

Chemical science·2026
Same author

Construction and Validation of a Model for Predicting Cervical Intraepithelial Neoplasia Grade II+: A Cross-Sectional Population Study via Machine Learning.

International journal of women's health·2025
Same author

Photochemical Generation of Peroxynitrite: Concurrent Inhibition of Glycolysis and Glutamine Metabolism for Enhanced Metabolic Therapy.

Journal of the American Chemical Society·2025

Related Experiment Video

Updated: Dec 24, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.7K

A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles.

Ze-Yong Li1, Jing-Jing Hu, Qi Xu

  • 1Key Laboratory of Biomedical Polymers of the Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. xz-zhang@whu.edu.cn.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary

This study introduces a novel drug delivery system using mesoporous silica nanoparticles (MSNs) that release the antitumor drug DOX within cancer cells, triggered by intracellular glutathione (GSH). This targeted approach enhances drug efficacy.

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.2K
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

11.4K

Related Experiment Videos

Last Updated: Dec 24, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.7K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.2K
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

11.4K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Mesoporous silica nanoparticles (MSNs) are widely explored for drug delivery.
  • Targeted drug delivery systems are crucial for enhancing cancer therapy efficacy and reducing side effects.
  • Intracellular stimuli-responsive systems offer precise drug release mechanisms.

Purpose of the Study:

  • To develop an intracellular glutathione (GSH)-responsive mesoporous silica nanoparticle (MSN-S-S-RGD) for targeted drug delivery.
  • To load the antitumor drug DOX onto the MSN-S-S-RGD system.
  • To evaluate the efficacy of the DOX@MSN-S-S-RGD system as a nanocarrier for cancer treatment.

Main Methods:

  • Immobilization of RGD-containing peptide onto MSNs via disulfide bonds to create a "gatekeeper" system.
  • Loading of DOX onto the porous structure of MSNs.
  • In vitro evaluation of drug loading, release kinetics, and cellular uptake via receptor-mediated endocytosis.
  • Assessment of drug release triggered by intracellular GSH cleavage of disulfide bonds.

Main Results:

  • The DOX@MSN-S-S-RGD system demonstrated efficient entrapment of DOX with minimal leakage.
  • The nanocarrier successfully accumulated in tumor cells through receptor-mediated endocytosis.
  • Cleavage of disulfide bonds by intracellular GSH triggered the release of DOX.
  • The system proved to be an effective nanocarrier for delivering antitumor drugs.

Conclusions:

  • The developed MSN-S-S-RGD system is a promising GSH-responsive nanocarrier for targeted cancer therapy.
  • The disulfide bond linkage allows for controlled drug release in response to the intracellular tumor microenvironment.
  • This targeted drug delivery strategy holds potential for improved therapeutic outcomes in cancer treatment.