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Polyacryloyl hydrazide based injectable & stimuli responsive hydrogels with tunable properties.

Anuj Kumar1, Sabindra K Samal, Rupesh Dash

  • 1Department of Chemistry, Rajiv Gandhi Institute of Petroleum Technology Raebareli, Ratapur Chowk, UP-229316, India. uojha@rgipt.ac.in.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary
This summary is machine-generated.

Injectable hydrogels were developed using polyacryloyl hydrazide and various cross-linkers. These stimuli-responsive materials show controlled drug release and excellent water retention, suitable for biomedical applications.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Hydrogels are crucial in biomedical applications, particularly for drug delivery.
  • Developing injectable and stimuli-responsive hydrogels with tunable properties remains a significant challenge.

Purpose of the Study:

  • To synthesize and characterize novel injectable and stimuli-responsive hydrogels based on polyacryloyl hydrazide.
  • To investigate the influence of cross-linker type and concentration on hydrogel properties, including swelling, mechanical strength, injectability, and drug release.
  • To evaluate the cytocompatibility and long-term water retention of the developed hydrogels.

Main Methods:

  • Hydrogels were synthesized via chemical or dual cross-linking pathways using polyacryloyl hydrazide with cross-linkers like dimethyl 2,2'-thiodiacetate, acrylic acid (AA), diethyl malonate, and polyethylene glycol diacrylate (PEGDA).
  • Cross-linking reactions were performed at room temperature or 70 °C.
  • Characterization included swelling ratio measurements, rheological analysis (yield stress, viscosity), drug release studies (Rhodamine B), water retention tests, and cytocompatibility assays.

Main Results:

  • Synthesized hydrogels exhibited swelling ratios ranging from 10-800%, dependent on cross-linker type/concentration, temperature, and pH.
  • Optimal storage modulus was achieved through a combination of chemical and physical cross-linking.
  • Gels demonstrated injectability, with viscosity decreasing significantly at high shear rates.
  • Controlled release of Rhodamine B (10-84%) occurred over 120 hours under physiological conditions.
  • Hydrogels showed excellent water retention (>95% for up to 40 days).
  • Samples cross-linked with AA and PEGDA displayed excellent cytocompatibility.

Conclusions:

  • Injectable and stimuli-responsive hydrogels based on polyacryloyl hydrazide were successfully synthesized.
  • The developed hydrogels possess tunable properties suitable for controlled drug delivery.
  • Excellent cytocompatibility and water retention capacity make these hydrogels promising for non-evasive biomedical applications.