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Updated: Dec 24, 2025

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
Published on: March 8, 2019
Synthesis, characterization, and self-assembly behaviors of a biodegradable and anti-clotting
Lixia Bao1, Xin Luo, Dandan Zhang
1School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. jlwang@ynu.edu.cn.
Abstract:
Anti-clotting EDTA-diol was successfully synthesized by an esterification reaction between EDTA-2Na and poly(ethylene glycol). Novel anti-clotting and biodegradable multi-block polyurethanes were then prepared by EDTA-diol and biodegradable poly(1,4-butylene adipate glycol) (PBA) as the soft chain, and 1,4-butanediol (BDO) and hexamethylene diisocyanate (HDI) as the hard chain, respectively. The effect of the EDTA-diol content in the soft chain of the prepared polyurethanes on mechanical properties, thermal stability, hydrophilicity, and anticoagulant ability was largely investigated by tensile tests, thermogravimetric analysis, contact angle and water absorption measurements, and hemolytic measurement. Self-assembly behaviors of the resulting polyurethanes were also evaluated by fluorescence spectroscopy and transmission electron microscopy. The prepared polyurethanes have large potential applications in the fields of biomedical materials such as tissue engineering and drug carriers.
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