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A proton-responsive ensemble using mesocellular foam supports capped with N,O-carboxymethyl chitosan for controlled
Qi Gan1, Jiaoyang Zhu, Yuan Yuan
1The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China. yyuan@ecust.edu.cn liucs@ecust.edu.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Abstract:
A novel pH-responsive mesocellular foam-based nanocarrier was fabricated by the covalent assembly of a water-soluble N,O-carboxymethyl chitosan via the crosslinking of GPTMS. The delivery systems show excellent protein loading with programmable release in an acid environment. Moreover, the released proteins still preserve their conformational and biological activity.
