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Updated: Dec 24, 2025
Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Facile synthesis of ionic liquid functionalized silica-capped CdTe quantum dots for selective recognition and
Dong-Yan Li1, Yi-Zhi Wang, Xiao-Li Zhao
1State Key Laboratory of Medicinal Chemical Biology (Nankai University), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China.
Abstract:
A facile and efficient approach for preparation of ionic liquid functionalized silica-capped CdTe QDs (CdTe/SiO2/IL) was proposed in this work. The imidazolium-based ionic liquid N-3-(3-trimethoxysilylpropyl)-3-methyl imidazolium chloride was introduced and anchored on the surface of silica-capped CdTe QDs by the sol-gel technique, which played the role of a recognition element due to the covalent coordination binding between the heme group of hemoprotein and the imidazolium cation in the ionic liquid. The synthetic CdTe/SiO2/IL was further characterized by elemental analysis, transmission electronic microscopy (TEM), X-ray photoelectron spectra (XPS) and Fourier transform infrared spectroscopy (FT-IR). Combining the merits of the fluorescence property of the QDs and the covalent interaction of the ionic liquid with hemoproteins, the CdTe/SiO2/IL exhibited high adsorption capacity and good specificity toward hemoproteins and also was successfully applied in the fluorescence detection of hemoprotein in biological fluid. The strategy provided a promising way to fabricate functionalized fluorescence materials as biomedical/chemical sensors for the separation and detection of hemoproteins in proteomics research.
