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In vitro effect of xipamide on sodium-potassium transport systems in human erythrocytes
P Lijnen1, R Fagard, J Staessen
1Department of Pathophysiology, University of Leuven, Belgium.
Abstract:
The in vitro effects of xipamide in a concentration range of 10(-8) to 10(-2) M were investigated on various Na+ and K+ transport systems in human red blood cells. Xipamide inhibited the anion carrier or DIDS-sensitive LiCO3- -influx starting from a concentration of 10(-5) M. However, a decrease in the Na+, K+-pump and the Na+, K+-cotransport activity and a rise in the passive permeability of the cell membrane was only observed starting from a concentration of 10(-4) M xipamide.