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A strategy for effective radioprotection by chitosan-based long-circulating nanocarriers
Yuan Zhou1, Song Hua, Jiahua Yu
1College of Chemistry, Chemical Engineering and Materials Science & School of Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China. dbhua_lab@suda.edu.cn fangsh@suda.edu.cn.
Abstract:
We demonstrate a strategy for effective radioprotection by chitosan-based long-circulating nanocarriers with radio-protective agents. The stable encapsulation does not restrain its radioprotective capability, and exhibits prolonged retention time in blood with a half-life of ∼10 h, thereby showing more beneficial effects than the pure agent in therapeutic efficacy for irradiated mice.
