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Updated: Dec 24, 2025

Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking
Published on: March 16, 2017
Intracellular pH-induced fluorescence used to track nanoparticles in cells
1National Engineering Research Center for Biomaterials, Sichuan University, 29# Wangjiang Road, Chengdu 610064, China. caojun@scu.edu.cn.
Abstract:
A nanoparticle with pH-induced fluorescence was reported for intracellular tracking. The fluorescence was evoked by the isomerization of the ring-closed form spiropyran (SP) to the ring-open form merocyanine (MC) in the weak acidic environment of cells. The SP-MC switch accelerated the dissociation of nanoparticles to trigger the release of trapped paclitaxel.
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