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Tailoring a two-dimensional graphene oxide surface: dual T1 and T2 MRI contrast agent materials
Erwin Peng1, Fenghe Wang, Suhui Tan
1Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore. mseer@nus.edu.sg msexuejm@nus.edu.sg.
Abstract:
A generalized strategy for developing a hybrid two-dimensional nanostructured dual T1-T2 MRI contrast agent (CA), by co-loading graphene oxide with both Mn-doped Fe3O4 (T2 agent) and MnO (T1 agent) magnetic nanoparticles, is reported. Typical T1/T2 signal quenching, due to magnetic coupling, was not observed because of the fair T1 CA separation distance from the T2 CA on the graphene oxide. The resultant two-dimensional nanostructured MRI CA complements the existing dual T1-T2 MRI CA libraries.
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