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Updated: Dec 24, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

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Published on: December 23, 2016

Biodegradable dextran vesicles for effective haemoglobin encapsulation.

Weiqi Wang¹, Shi Liu, Yubin Huang

¹State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiez@ciac.ac.cn.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

This summary is machine-generated.

Biodegradable dextran vesicles were created using dextran and poly(l-lactide) (PLA) for potential blood substitute applications. These stable hemoglobin vesicles (HbVs) effectively encapsulated hemoglobin, retaining its oxygen affinity.

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology

Background:

Development of effective drug delivery systems and artificial blood substitutes is crucial.
Biodegradable polymers offer promising biocompatibility and tunable properties for biomedical applications.
Dextran-based nanoparticles have shown potential for various therapeutic uses.

Purpose of the Study:

To synthesize and characterize biodegradable dextran-poly(l-lactide) (PLA) copolymer nanoparticles.
To investigate the self-assembly behavior and morphology of these nanoparticles.
To encapsulate hemoglobin (Hb) within the vesicles and evaluate their potential as blood substitutes.

Main Methods:

Synthesis of amphiphilic dextran-g-PLA copolymer via carboxyl-terminated PLA coupling to dextran.
Self-assembly of the copolymer into nanoparticles using a dialysis procedure.
Characterization of nanoparticle morphology and size using transmission electron microscopy (TEM) and dynamic light scattering (DLS).
Encapsulation of hemoglobin (Hb) and assessment of oxygen affinity.

Main Results:

Successfully developed stable, biodegradable dextran-PLA vesicles with controllable morphology.
Demonstrated successful encapsulation of hemoglobin within the vesicles.
Observed that the oxygen affinity of encapsulated hemoglobin in HbVs was comparable to free Hb.
Indicated that nanoparticle morphology can be tuned by adjusting the dextran to PLA mass ratio.

Conclusions:

Biodegradable dextran-PLA vesicles are a stable and promising platform for hemoglobin encapsulation.
These hemoglobin vesicles (HbVs) show potential as effective blood substitutes.
The tunable nature of the vesicles suggests broad applicability in drug delivery and regenerative medicine.