Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Solubility Equilibria: Overview01:09

Solubility Equilibria: Overview

1.3K
When a substance such as sodium chloride is added to water, it dissolves, forming an aqueous solution. The extent of dissolution is called solubility. The process of dissolution can exist in equilibrium, just like other chemical processes. Solubility equilibria are also called precipitation equilibria because the process of solubility can be reversible. The reverse of the solubility process is called precipitation.
Solubility is important in biological and environmental processes. A notable...
1.3K
Factors Affecting Solubility04:01

Factors Affecting Solubility

36.4K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
36.4K
Solubility03:00

Solubility

20.6K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
20.6K
Solubility Equilibria03:07

Solubility Equilibria

56.4K
Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
56.4K
Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

67.7K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
67.7K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

157
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
157

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural Origins of High MoO<sub>3</sub> Solubility in Peraluminous Borosilicate Glasses.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

Brain signal variability is reduced during self-face processing irrespective of emotional facial expressions: Evidence from multiscale entropy analysis.

Cortex; a journal devoted to the study of the nervous system and behavior·2025
Same author

Optical properties and spin states of inter-layer carbon defect pairs in hexagonal boron nitride: a first-principles study.

Physical chemistry chemical physics : PCCP·2025
Same author

Effects of subliminal emotional facial expressions on language comprehension as revealed by event-related brain potentials.

Scientific reports·2025
Same author

Data driven design of ultra high performance concrete prospects and application.

Scientific reports·2025
Same author

Fukui Function and Fukui Potential for Solid-State Chemistry: Application to Surface Reactivity.

Journal of chemical theory and computation·2025

Related Experiment Video

Updated: Dec 24, 2025

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
10:17

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors

Published on: October 9, 2016

16.0K

Structure-solubility relationships in fluoride-containing phosphate based bioactive glasses.

Yaqoot Shaharyar1, Eric Wein, Jung-Ju Kim

  • 1Department of Materials Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. ashutosh.goel@rutgers.edu.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary

Fluoride in bioactive glasses impacts their dissolution and bioactivity. This study used experiments and simulations to understand how fluoride affects phosphate-based glasses, revealing insights for designing better biomaterials.

More Related Videos

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion
06:48

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion

Published on: May 9, 2025

1.1K
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
14:49

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

5.5K

Related Experiment Videos

Last Updated: Dec 24, 2025

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
10:17

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors

Published on: October 9, 2016

16.0K
Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion
06:48

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion

Published on: May 9, 2025

1.1K
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
14:49

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

5.5K

Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Biomedical Engineering

Background:

  • Fluoride-releasing bioactive glasses, typically soda-lime-silica based, exhibit slow dissolution and potential negative impacts of fluoride on bioactivity.
  • Biodegradable phosphate-based bioactive glasses offer an alternative for applications requiring rapid ion release.
  • Understanding the relationship between composition, structure, and solubility is crucial for designing novel biomaterials.

Purpose of the Study:

  • To investigate the impact of fluoride ions on the structure and chemical dissolution of phosphate-based bioactive glasses.
  • To establish composition-structure-property relationships for fluoride-containing phosphate glasses.
  • To explore fluoride-modified phosphate glasses as potential advanced biomaterials.

Main Methods:

  • Utilized a combination of experimental techniques and Molecular Dynamics (MD) simulations.
  • Analyzed glasses in the system 10Na2O-(45-x)CaO-45P2O5-xCaF2 (x = 0-10 mol%).
  • Investigated chemical dissolution in various pH buffers, apatite formation in simulated body fluid (SBF), and in vitro cytotoxicity on mesenchymal stem cells (MSCs).

Main Results:

  • Nuclear Magnetic Resonance (NMR) and MD simulations showed Q2 phosphate units dominate the structure, with fluoride associating with network modifiers.
  • Fluoride incorporation influenced the phosphate network's polymerization state.
  • Dissolution rates and bioactivity varied with fluoride content and solution pH.

Conclusions:

  • Fluoride ions significantly alter the atomic-scale structure and dissolution behavior of phosphate-based bioactive glasses.
  • The findings provide a foundation for tailoring the properties of these glasses for specific biomedical applications.
  • Phosphate-based glasses with controlled fluoride content show promise as advanced biomaterials.