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Updated: Dec 24, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Modulating the cellular microenvironment with disulfide-containing nanoparticles as an auxiliary cancer treatment
Jingmei Yang1, Yongchao Duan, Xuezhu Zhang
1Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China. yongjian_wang@nankai.edu.cn.
Abstract:
Stimuli-responsive drug release nanoparticles are of particular interest due to their enhanced effects and reduced systemic toxicities in the area of cancer therapeutics. The effect of these nanoparticles on the cellular microenvironment has not yet been clearly defined. In this context, redox-responsive nanoparticles were synthesized with disulfide-containing linkages. These nanoparticles depleted the cellular GSH level and modulated the cellular redox microenvironment to more oxidizing conditions. The resulting drug-encapsulated nanoparticles showed improved cytotoxicity, apoptosis, and invasion inhibition of metastatic cancer cells. Moreover, these improvements had a direct correlation with the cellular redox status modulated by nanoparticles. The present study provides a new strategy for designing redox-responsive drug carriers to improve the sensitivity of cells to anticancer drugs and enhance the therapeutic efficacy in metastatic cancer.
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