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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
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Nanofibrous polylactide composite scaffolds with electroactivity and sustained release capacity for tissue
Jing Chen1, Juan Ge, Baolin Guo
1Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China. baoling@mail.xjtu.edu.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Researchers developed novel electroactive composite scaffolds using polylactide nanofibers and polyurethane-urea nanoparticles for tissue engineering. These scaffolds exhibit sustained drug release and promote cell growth, showing promise for muscle and nerve regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Developing advanced scaffolds is crucial for effective tissue regeneration.
- Electroactive materials offer unique properties for stimulating cellular responses.
- Sustained drug delivery from scaffolds enhances therapeutic outcomes.
Purpose of the Study:
- To fabricate electroactive composite scaffolds with sustained drug release capabilities.
- To investigate the impact of scaffold architecture and electroactivity on cell behavior.
- To evaluate the potential of these scaffolds for muscle and nerve tissue engineering.
Main Methods:
- Fabrication of electroactive nanoparticles from polyurethane-urea copolymers.
- Creation of composite scaffolds via electrospray/electrospinning of nanoparticles onto polylactide nanofibers.
- Characterization of scaffold morphology using Scanning Electron Microscopy (SEM).
- Assessment of drug release kinetics using ibuprofen and rutin as model drugs.
- Evaluation of L929 fibroblast proliferation and C2C12 myoblast proliferation and differentiation.
Main Results:
- Nanoparticles exhibited sustained release kinetics for both hydrophobic and hydrophilic drugs.
- Composite scaffolds demonstrated successful universal coating of nanoparticles on polylactide nanofibers.
- Drug release mechanisms were investigated, confirming sustained release profiles.
- Rutin-loaded scaffolds supported L929 fibroblast proliferation.
- Aligned electroactive composite nanofibers showed a synergistic effect on C2C12 myoblast proliferation and differentiation.
Conclusions:
- Electroactive nanofibrous composite scaffolds possess significant sustained release properties.
- The combination of electroactivity and aligned morphology synergistically enhances myoblast proliferation and differentiation.
- These scaffolds hold substantial potential for applications in muscle and nerve regeneration.
- The developed materials offer a promising platform for advanced tissue engineering strategies.
