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Updated: Dec 24, 2025

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In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage
Published on: January 11, 2012
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Target-triggered autonomous assembly of DNA polymer chains and its application in colorimetric nucleic acid detection
Jianyuan Dai1, Hongfei He, Zhijuan Duan
1College of Chemistry, Sichuan University, Chengdu 610064, China. daijy@scu.edu.cn guoy@scu.edu.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Abstract:
A novel target-triggered DNA autonomous assembly pathway for the formation of one-dimensional DNA polymer chains was proposed based on the catalyzed hairpin assembly and sticky end self-assembly, which led to an enzyme-free and signal amplified gold nanoparticle (AuNP) based colorimetric nucleic acid assay with picomolar sensitivity and specificity.

