Related Experiment Video
Updated: Dec 24, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo
1Key Laboratory of Drug Targeting and Delivery, Ministry of Education, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China. yfu4@scu.edu.cn.
Abstract:
A series of self-assembled mixed micelles composed of TPGS and Pluronics were fabricated and their cellular uptake and exocytosis behaviors were studied in 2D cell and 3D tumor spheroid models. Together with in vivo efficacy studies, our results demonstrate that TPGS is not only critical to stabilize the mixed micelle structure but also to improve drug loading and facilitate cell penetration and accumulation.

