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Updated: Dec 24, 2025
Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2
Anakin C S Leung1, Engui Zhao, Ryan T K Kwok
1Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, Division of Biomedical Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China. tangbenz@ust.hk.
Abstract:
A bioprobe, TPE-Zn2BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2O2. TPE-Zn2BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.
