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Biofilms01:29

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Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
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Biodegradable shape memory polymers functionalized with anti-biofouling interpenetrating polymer networks.

I Dueramae1, M Nishida, T Nakaji-Hirabayashi

  • 1Frontier Research Core for Life Sciences, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan. nakaji@eng.u-toyama.ac.jp.

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|April 9, 2020
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Summary
This summary is machine-generated.

Researchers developed novel biodegradable shape memory polyurethanes (SMPUs) with excellent mechanical and shape recovery properties. These advanced SMPUs, when combined with a zwitterionic polymer, exhibit significant anti-biofouling capabilities, making them promising for biomedical applications.

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Area of Science:

  • Polymer Science
  • Biomaterials Engineering
  • Materials Science

Background:

  • Biomedical devices require materials with specific mechanical, degradation, and surface properties.
  • Shape memory polymers (SMPs) offer dynamic capabilities, but often lack biodegradability or biocompatibility.
  • Developing advanced SMPs with enhanced functionalities is crucial for next-generation medical applications.

Purpose of the Study:

  • To synthesize and characterize novel biodegradable shape memory polyurethanes (SMPUs) with high mechanical performance.
  • To investigate the shape memory behavior and degradation profiles of the developed SMPUs.
  • To enhance the SMPUs with anti-biofouling properties for biomedical applications using an interpenetrating polymer network (IPN) approach.

Main Methods:

  • Synthesis of SMPUs using poly(ε-caprolactone-co-γ-butyrolactone) (PCLBL), diol/triol chain extenders, and 1,6-hexamethylene diisocyanate.
  • Mechanical testing and shape recovery assessments at 80 °C.
  • Interpenetration of SMPU sheets with poly(carboxymethyl betaine) (PCMB) via the IPN method.
  • Surface characterization using water contact angle measurements.
  • Evaluation of protein adsorption and cell adhesion on modified SMPU surfaces.

Main Results:

  • All synthesized SMPUs demonstrated high mechanical properties.
  • SMPU sheets prepared with a triol-chain extender showed complete shape recovery at 80 °C.
  • Degradation products of the SMPUs were found to be non-toxic.
  • PCMB incorporation significantly reduced surface water contact angle from 87° to ~30°.
  • The resulting SMPU-IPN sheets exhibited substantial suppression of protein adsorption and cell adhesion.

Conclusions:

  • Novel biodegradable SMPUs based on PCLBL exhibit excellent mechanical and shape memory properties.
  • The incorporation of PCMB via IPN effectively imparts significant anti-biofouling characteristics.
  • These PCLBL-PU-based SMPU-IPN materials are highly promising for diverse biomedical applications, including aneurysm embolization and anti-adhesion membranes.