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Aptamer application in targeted delivery systems for diagnosis and treatment of breast cancer
Mahin Shahdordizadeh1, Rezvan Yazdian-Robati, Mohammad Ramezani
1Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:
Breast cancer is the second leading cause of cancer deaths in women and, due to its diverse morphological features, variable clinical outcome and response to different therapeutic options, is known as a highly heterogeneous disease. Aptamers are a class of therapeutic oligonucleotides that are rapidly generated through the SELEX (Systematic Evolution of Ligands by EXponential enrichment) process. The unique properties of aptamers such as high binding affinity and selectivity, low or no immunogenicity and toxicity, low cost and thermal stability make them good potential pharmaceutical agents. In this review, we present the recent progress of aptamer application in targeted delivery systems for imaging and treatment of breast cancer. Furthermore, some analytical approaches such as electrochemical and optical aptasensors are introduced for the detection and diagnosis of breast cancer. Finally, we discuss the problems and challenges of aptamer application in this field.
Insights
Aptamers show promise for targeted breast cancer therapy and diagnostics. This review highlights their application in drug delivery, imaging, and aptasensor development for improved breast cancer management.
Area of Science:
- Biotechnology
- Oncology
- Molecular Biology
Background:
- Breast cancer is a heterogeneous disease with variable outcomes.
- Aptamers are therapeutic oligonucleotides with high affinity and selectivity.
- Aptamers offer potential advantages over traditional therapies due to low toxicity and cost.
Purpose of the Study:
- To review recent advancements in aptamer applications for breast cancer.
- To explore aptamers in targeted delivery systems for imaging and treatment.
- To discuss aptasensors for breast cancer detection and diagnosis.
Main Methods:
- Systematic Evolution of Ligands by EXponential enrichment (SELEX) for aptamer generation.
- Review of literature on aptamer-based targeted delivery systems.
- Analysis of aptasensor technologies for breast cancer detection.
Main Results:
- Aptamers demonstrate significant potential in targeted breast cancer therapy and imaging.
- Electrochemical and optical aptasensors show promise for sensitive breast cancer diagnosis.
- Aptamers offer a viable alternative for drug delivery systems.
Conclusions:
- Aptamers are valuable tools for targeted breast cancer treatment and diagnostics.
- Further research is needed to overcome challenges in clinical application.
- Aptamer technology holds promise for advancing breast cancer care.
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