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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Surface modification of silica nanoparticles using 4-aryloxy boron dipyrromethene (BODIPY) enhances skin permeation
Takaki Amamoto1, Satoshi Hirakawa, Tomofumi Santa
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. masaru-kato@umin.ac.jp.
Abstract:
4-Aryloxy boron dipyrromethene (BODIPY) modification of the surface of silica nanoparticles (NPs) improved permeability through the membrane of HaCaT skin cells and swine skin tissue. The 35 nm BODIPY-modified NPs penetrated tape-stripped skin and reached the dermis within 1 h. Since these NPs can encapsulate a variety of molecules including macromolecules, they are expected to serve as effective carriers for the delivery of drugs, genes, and other compounds through skin and into cells.
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