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A hemocompatible polyurethane surface having dual fibrinolytic and nitric oxide generating functions
Hao Gu1, Xianshuang Chen, Xiaoli Liu
1State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. liuxiaoli@suda.edu.cn wzqwhu@suda.edu.cn.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Developing novel blood-compatible materials is crucial. This study created a dual-function surface that prevents clot formation and releases nitric oxide (NO) to inhibit platelet activation and smooth muscle cell proliferation, enhancing material safety.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Vascular Biology
Background:
- Thrombus formation on blood-contacting materials remains a significant challenge, despite extensive research.
- Existing strategies to prevent surface-induced clotting have proven largely ineffective.
- An alternative approach involves designing surfaces that can actively lyse nascent clots and inhibit platelet activation.
Purpose of the Study:
- To develop a novel dual-functioning biomaterial surface.
- To create a surface with both fibrinolytic activity and nitric oxide (NO) releasing capabilities.
- To mitigate thrombus formation and related complications in blood-contacting applications.
Main Methods:
- Graft polymerization of poly(oligo(ethylene glycol) methyl ether methacrylate-co-6-amino-2-(2-methacylamido)-hexanoic acid) (poly(OEGMA-co-LysMA)) onto a vinyl-functionalized polyurethane (PU) surface, creating PU-POL.
- Immobilization of selenocystamine onto the PU-POL surface via covalent attachment to enable NO generation.
- Characterization of the resulting surface for protein resistance, fibrinolytic activity, and NO release.
Main Results:
- The synthesized PU-POL surface exhibited excellent protein resistance due to the poly(OEGMA) component.
- The immobilized poly(LysMA) demonstrated effective clot-lysing properties.
- The selenocystamine-modified surface successfully generated NO, inhibiting platelet and smooth muscle cell adhesion and proliferation.
Conclusions:
- A novel dual-functioning surface with integrated fibrinolytic and NO-releasing properties was successfully constructed.
- This innovative biomaterial holds significant potential for reducing thrombotic complications in medical devices.
- The developed surface represents a promising advancement in the field of blood-compatible materials.
