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Updated: Dec 24, 2025
Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
Lactoferrin-modified nanoparticles loaded with potent antioxidant Mn-porphyrins exhibit enhanced antioxidative
Motoyuki Matsuho1, Riku Kubota, Shoichiro Asayama
1Department of Applied Chemistry, Tokyo Metropolitan University, Minami-osawa 1-1, Hachioji, Tokyo, Japan. kawakami-hiroyoshi@tmu.ac.jp.
Abstract:
In this study, for efficient intranasal brain delivery, we have prepared lactoferrin (Lf)-modified nanoparticles loaded with an amphiphilic Mn-porphyrin derivative, MndMImP3P (MnP) (Lf-NP-MnP). MndMImP3P was loaded into the nanoparticles with good loading efficiency. The stability of the resulting Lf-NP-MnP was sufficient for intranasal brain delivery. Lf on the surface of Lf-NP-MnP was significantly recognized by the Lf receptor, which leads to enhanced cellular uptake of MnP and efficient transcytosis. Furthermore, Lf-NP-MnP exhibited antioxidative activity in vitro experiment using a transwell assay as a model of intranasal brain delivery. Our result in this study is one step forward for efficient brain delivery of Mn-porphyrin derivatives to cure neurodegenerative diseases.
