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Updated: Jan 29, 2026
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Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
757
[Pathophysiology of bone disorder after total gastrectomy]
M Sugiyama1, C Y Hsu-Chang, Y Sato
1Second Department of Surgery, School of Medicine, Yokohama City University, Japan.
Nihon Geka Gakkai Zasshi
|September 1, 1988
Summary
Total gastrectomy leads to significant bone disorder in patients and rats, resembling osteomalacia. Malabsorption of vitamin D and calcium due to poor intake and diarrhea are likely causes.
Area of Science:
- Gastroenterology and Bone Metabolism
- Surgical Outcomes and Nutritional Deficiencies
Context:
- Total gastrectomy, a major surgical procedure, can lead to significant post-operative complications.
- Bone health is a critical concern following extensive gastrointestinal surgery.
Purpose:
- To investigate the prevalence and characteristics of bone disorder after total gastrectomy.
- To explore the underlying mechanisms contributing to bone metabolism disturbances post-gastrectomy.
Summary:
- Clinical study: 63% of patients exhibited bone abnormalities, 52% hypocalcemia, and 47% elevated alkaline phosphatase (A1-P). Calcium infusion tests suggested osteomalacia.
- Animal study: Total gastrectomy in rats showed decreased bone density, reduced food intake, lower serum calcium and vitamin D, increased fecal lipids, and impaired intestinal calcium absorption.
- Findings indicate a progressive bone deterioration over time post-surgery, with malabsorption of vitamin D and calcium as primary etiological factors.
Impact:
- Highlights the significant risk of osteomalacia following total gastrectomy.
- Underscores the importance of monitoring bone metabolism and nutritional status in post-gastrectomy patients.
- Suggests potential therapeutic targets focusing on calcium and vitamin D supplementation and management of malabsorption.
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