Cobalt phosphide nanowire array as an effective electrocatalyst for non-enzymatic glucose sensing

Area of Science:

• Electrochemistry
• Materials Science
• Nanotechnology

Background:

• Electrochemical sensing platforms are crucial for molecular detection.
• Nanoarray architectures offer ideal designs for enhanced sensing capabilities.
• Cobalt phosphide (CoP) nanomaterials show promise in catalytic applications.

Purpose of the Study:

• To develop and evaluate a novel cobalt phosphide nanowire array on titanium mesh (CoP NA/TM) as a non-enzymatic electrochemical glucose sensor.
• To investigate the catalytic activity and analytical performance of the CoP NA/TM electrode for glucose electrooxidation.

Main Methods:

• In situ growth of cobalt phosphide nanowire array on a titanium mesh substrate.
• Fabrication of a non-enzymatic electrochemical glucose sensor using the CoP NA/TM electrode.
• Characterization of the sensor's analytical performance, including response time, linear range, detection limit, sensitivity, selectivity, and stability.

Main Results:

• The CoP NA/TM electrode exhibited high catalytic activity for glucose electrooxidation.
• The non-enzymatic glucose sensor demonstrated a fast response time (<5 s).
• Superior analytical performance was achieved with a wide linear range (0.0005-1.5 mM), low detection limit (0.1 μM), and high sensitivity (5168.6 μA mM⁻¹ cm⁻²).
• The sensor showed remarkable selectivity and long-term stability for glucose detection.
• Successful application of the glucose biosensor in human blood serum and fruit juice samples was demonstrated.

Conclusions:

• The CoP NA/TM nanostructure is a highly effective material for non-enzymatic electrochemical glucose sensing.
• This developed glucose biosensor offers excellent analytical performance and practical applicability in complex biological and food samples.
• The CoP NA/TM array presents a promising platform for advanced electrochemical biosensing applications.