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Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles
Chang Lei1, Chun Xu, Amanda Nouwens
1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. c.yu@uq.edu.au.
Journal of Materials Chemistry. B
|April 9, 2020
Abstract:
An ultrasensitive enzyme-linked immunosorbent assay (ELISA+) has been developed by using dendritic mesoporous silica nanoparticles (DMSNs) with high horseradish peroxidase (HRP) loading and easily accessible pore channels for signal amplification. A 2000 times enhancement of detection sensitivity compared to a commercial ELISA kit for insulin detection in serum is achieved.

