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Photothermal triggered protein release from an injectable polycaprolactone-based microspherical depot
Chunling Ge1, Johan S Basuki, Jacinta White
1Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology, Beijing, P. R. China. twtan@mail.buct.edu.cn.
Abstract:
Upon exposure to visible light, controlled multiple dose protein release was demonstrated by using a microspherical depot composed of biodegradable poly(ε-caprolactone) (PCL), bovine serum albumin (BSA) or horseradish peroxidase (HRP) as model protein, polymer-coated gold nanoparticles as photothermal component, which can potentially reduce the number of invasive therapeutic injections.
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