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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

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Published on: August 8, 2022

Core-shell-structured nonstoichiometric bioceramic spheres for improving osteogenic capability.

Chen Zhuang¹, Xiurong Ke, Zhouwen Jin

¹Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China. zhrgou@zju.edu.cn.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

Tailoring core-shell bioactive ceramic spheres with specific ion doping and component distribution optimizes bone regeneration. This controlled biodegradation and osteogenic response is crucial for effective bone repair applications.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

Biomaterials Science
Regenerative Medicine
Bioceramics

Background:

Advancing bone regenerative medicine requires porous biomaterial constructs with controlled bioactivity and biodegradation.
The layered structure of hybrid bioceramics can influence time-dependent biological performance and osteogenic responses.

Purpose of the Study:

To develop and evaluate core-shell structured nonstoichiometric calcium silicate (nCSi) spheres with controlled spatiotemporal distribution of bi-component nCSi.
To investigate the effect of ion doping (Sr, Mg) and component distribution on the osteogenic capability and biodegradation of nCSi spheres for bone regeneration.

Main Methods:

Core-shell nCSi ceramic spheres were fabricated using a coaxial bilayer nozzle with alginate slurries containing Sr- or Mg-doped nCSi.
Spheres underwent drying and sintering treatments.
The biodegradation and bone regeneration rates of implanted spheres in rabbit femoral bone defects were evaluated at 6-18 weeks post-implantation.

Main Results:

CSi-Mg6 and CSi-Mg10 shells exhibited improved sintering and denser structures, retarding ion release and biodegradation compared to CSi-Sr4@CSi-Sr4.
CSi-Sr4@CSi-Mg10 showed slow biodegradation and new bone regeneration, while CSi-Sr4@CSi-Sr4 degraded rapidly with low osteogenic capacity.
CSi-Sr4@CSi-Mg6 spheres demonstrated optimal biodegradation and osteogenic activity over time.

Conclusions:

Slight tailoring of doping ions and component distribution in nCSi core-shell spheres is beneficial for adjusting osteogenesis.
This core-shell design strategy offers a versatile approach for producing bioactive ceramics for bone regeneration and repair.