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Nanomaterials engineering for drug delivery: a hybridization approach
M Rezaa Mohammadi1, Amirali Nojoomi, Masoud Mozafari
1Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304, USA.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Hybrid nanoparticle (NP) systems combine multiple materials to improve drug delivery efficiency. This strategy enhances targeting and overcomes biological barriers, paving the way for advanced nanotherapeutics.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Significant advancements in materials science have enabled the creation of novel nanoparticle (NP)-mediated drug delivery systems.
- Current nanotherapeutic technologies face challenges with efficiency and clinical trial success due to poor target accumulation.
Purpose of the Study:
- To review techniques, materials, and the pros and cons of hybrid nano-vesicles for drug delivery.
- To highlight the benefits of hybridization in overcoming biological barriers for enhanced drug delivery.
Main Methods:
- Comprehensive literature review of hybridization strategies for nano-vesicle drug delivery.
- Analysis of materials, techniques, advantages, and drawbacks of hybrid systems.
Main Results:
- Hybridization of multiple materials in NPs offers a promising strategy to improve drug delivery efficiency.
- Each component in a hybrid system can fulfill specific roles for multipurpose delivery.
Conclusions:
- Hybrid nano-vesicles represent a significant advancement for overcoming biological barriers in drug delivery.
- Multifunctional hybrid carriers are crucial for future developments in efficient nanodrug delivery systems.
