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Injectable MnSr-doped brushite bone cements with improved biological performance.
P M C Torres1, A Marote, A R Cerqueira
1Department of Materials and Ceramic Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal. ptorres@ua.pt.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
This study enhances calcium phosphate cements (CPCs) for bone repair by co-doping with manganese and strontium and adding sugars. The improved CPCs show better injectability, strength, and cell growth for bone regeneration.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Tissue Engineering
Background:
- Calcium phosphate cements (CPCs) are crucial bone substitutes for minimally invasive surgeries.
- Achieving a balance between mechanical strength, injectability, and biological performance in CPCs remains a challenge.
- Current CPCs often compromise on injectability or strength, limiting their clinical application.
Purpose of the Study:
- To develop novel calcium phosphate cements (CPCs) with enhanced mechanical and injectability properties.
- To improve the biological performance of CPCs for better bone regeneration.
- To investigate the combined effects of doping and saccharide addition on CPC characteristics.
Main Methods:
- Co-doping beta-tricalcium phosphate (β-TCP) powder with strontium (Sr) and manganese (Mn).
- Incorporating saccharides (sucrose or fructose) into the setting liquid of the CPCs.
- Evaluating injectability, wet compressive strength, and in vitro biological performance using MG63 osteoblastic cells.
Main Results:
- The combined doping and saccharide addition resulted in fully injectable CPCs.
- Significant increase in wet compressive strength compared to undoped or Sr-doped CPCs.
- Enhanced proliferation, collagen-I secretion, and cell growth behaviour of osteoblastic cells on the modified CPC surfaces.
Conclusions:
- Co-doping CPCs with Mn/Sr and adding sucrose significantly improves mechanical and injectability properties.
- The enhanced CPCs demonstrate superior in vitro biological performance, promoting osteoblastic cell activity.
- These novel CPCs show great promise as advanced materials for bone regeneration and tissue engineering applications.
