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Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres
Published on: June 1, 2012
A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: preparation and application
Yong-Gang Zhang1, Ying-Jie Zhu, Feng Chen
1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China. y.j.zhu@mail.sic.ac.cn.
Abstract:
In this work, a novel ultralong hydroxyapatite microtube (HMT)-chitosan (CHS) composite scaffold has been successfully prepared. The mechanical properties of the HMT-CHS composite scaffold is greatly improved compared with the CHS-hydroxyapatite nanorod scaffold and the pure chitosan scaffold. By using gentamicin sulfate (GS) as the model drug, the GS-loaded HMT-CHS composite scaffold has a high drug loading capacity, sustained drug release behavior and high antibacterial activity. The as-prepared HMT-CHS composite scaffold has promising applications in various fields such as drug delivery and bone defect repair.
