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Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
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Highly selective organic transistor biosensor with inkjet printed graphene oxide support system
Dong-Hoon Lee1, Hee-Sang Cho, Dawoon Han
1School of Electronic and Electrical Engineering, Sungkyunkwan University, Suwon, Gyeonggi 16419, South Korea. yongsang@skku.edu.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
This study introduces a novel graphene oxide support system (GOSS) integrated with pentacene field-effect transistors (FETs) for highly selective biosensing. The GOSS-pentacene FET biosensor demonstrates effective detection of DNA and cancer cells, paving the way for low-cost medical diagnostics.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Existing field-effect transistors (FETs) lack general methods for specific analyte detection.
- Developing sensitive and selective biosensors is crucial for early disease diagnosis.
Purpose of the Study:
- To develop a novel pentacene-based FET biosensor using a graphene oxide support system (GOSS).
- To demonstrate the capability of the GOSS-pentacene FET for detecting specific biomolecules and circulating tumor cells.
Main Methods:
- Inkjet printing of functionalized graphene oxide (GO) ink to create a GOSS on pentacene FETs.
- Functionalizing the GOSS with specific moieties for targeted biomaterial capture.
- Detecting artificial DNA and circulating tumor cells as proof-of-concept.
Main Results:
- The GOSS provided modular receptor sites on the pentacene FET without device alteration.
- Significant changes in FET mobility were observed upon target biomolecule capture.
- High selectivity was achieved, detecting 0.1 pmoles of target DNA and a few cancer cells.
Conclusions:
- The GOSS-pentacene FET biosensor offers a valuable platform for medical diagnosis.
- The proposed sensor is suitable for mass production due to its low-cost and effortless fabrication.
- This technology holds promise for advancing point-of-care diagnostics.
